Sergei is Professor of Pediatrics at the University of Florida. Over the course of the past 30 years, Sergei’s research has focused on two areas: 1) designing better gene therapy vehicles using recombinant adeno-associated virus (rAAV) vectors, and 2) energy metabolism. Specifically, his laboratory has developed a novel Baculovirus-based system for highly efficient production of rAAV vectors. In addition, he has developed highly complex combinatorial library incorporating 2x108 AAV capsid variants as a universal source of custom-designed vectors targeted to specific cell types, tissues, and organs.
Sergei’s distinctive expertise has enabled him to interrogate problems at the intersection of two areas – gene therapy vector design and production. He has developed many of the methods for purification and quality control of AAV vectors and has pioneered the development of improved capsid engineering methods and baculovirus vector production platforms.
Sergei obtained his B.S. degree from Kiev State University, Kiev, Ukraine, and his Ph.D. degree from the Institute of Molecular Biology and Genetics, Kiev, Ukraine. He carried out his postdoctoral training at the State University of New York at Stony Brook, Stony Brook, NY, in the laboratory of Dr. Nicholas Muzyczka.